Skrevet av Emne: Impact of weight loss on fat cell size/number, leptin  (Lest 1441 ganger)

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Impact of weight loss on fat cell size/number, leptin
« : 19. september 2005, 09:10 »
J Clin Endocrinol Metab. 2005 Aug 30; [Epub ahead of print] Related Articles, Links

Long-term prospective and controlled studies demonstrate adipose tissue hypercellularity and relative leptin deficiency in the post-obese state.

Lofgren P, Andersson I, Adolfsson B, Leijonhufvud BM, Hertel K, Hoffstedt J, Arner P.

Karolinska Institutet, Clinical Research Center and Department of Medicine Karolinska University Hospital, Huddinge Stockholm, Sweden.

Context. Enlarged fat cells and leptin hypersecretion are hallmarks of common obesity. Objective. To investigate fat cell size and leptin production in the basal state following long-term steady-state weight reduction to the non-obese state. Design. Prospective case-control study. 3 +/- 1 (mean +/- SD) years duration. Patients. Twenty-five obese women (cases). Each case was compared with a control subject matched for age, sex and BMI at nadir of weight for the cases. Setting. University hospital. Intervention. The subjects were followed until they reached a steady-state weight reduction following lifestyle modification or bariatric surgery (cases). Treatment target was the non-obese state (BMI< 30 kg/m(2)). sc adipose tissue secretion of leptin, serum leptin levels and fat cell volume were determined after an overnight fast. Results Ten obese women (40%) reached the non-obese state. This was accompanied by marked decreases in fat cell volume, leptin secretion and serum leptin concentrations (P < 0.0001). The post-obese cases had 43% smaller fat cell volume (P = 0.0008), 68% lower adipocyte leptin production (P = 0.001) and 54% lower serum leptin levels (P = 0.0007) than control subjects, despite almost identical percentage body fat in the two groups. Fat cell volume, but not percentage body fat or BMI, was directly proportional to leptin secretion and serum leptin concentrations. Conclusion. Adipose tissue hyperplasia (too many small fat cells) and low leptin production resulting in relative hypoleptinemia in the fasting (basal) state are common features of the post-obese state in women.
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