Sticky : "Komplett" oversikt over tilskudd!

[Benpressmannen]

Jeg har mange fler som jeg blir å legge ur, skal trene nå, så hjem å lette etter de også blir jeg å legge de ut her...

Takk for nå.

[jens-mulla]

Håper du legger ut dette benpressmannen!

Har veldig sansen får begge Viru'ene, de kan virkelig sine saker.

[Benpressmannen]

Ok her er den litt tvilsome fra 1988 + en litt nyere test ref

Ecdysterone!
Chermnykh NS et al. Effects of methandrostenolone and ecdisterone on physical endurance of animals and protein metabolism in skeletal muscle. Farmakologiia Toksikologiia 51(6), 57-60; 1988

Di pasquale MG. Ecdysteron. Drugs in sports 3(1), 3-4; 1995

[Benpressmannen]

Så en litt tvilsom dyre studie.

Experientia. 1996 Jul 15;52(7):702-6.  Related Articles, Links  


Insect hormones in vertebrates: anabolic effects of 20-hydroxyecdysone in Japanese quail.

Slama K, Koudela K, Tenora J, Mathova A.

Institute of Entomology, Czech Academy of Sciences, Praha, Czech Republic.

Ecdysteroids are hormones controlling cell proliferation, growth and the developmental cycles of insects and other invertebrates. They are occasionally present in various unrelated plants for no apparent reason; no phytohormonal function has yet been identified. In certain cases, ecdysteroids are accumulated to high levels in leaves, roots or seeds. Some ecdysteroid-containing plants have been known as medicinal plants for centuries. One of them, Leuzea carthamoides Iljin (Asteraceae), growing in Central Asia, contains 0.4% ecdysteroid in dry roots and 2% in seeds. A pharmacological preparation from this plant, "Ecdisten', is already available as a commercial preparation for its anabolic, tonic and other effects, for medical use (review). It remained problematic, however, whether ecdysteroids were truly responsible for these effects, because Leuzea contains a number of other biologically active compounds in addition to ecdysteroids. We extracted and purified ecdysteroids from the seeds of Leuzea. With 6 g of 96% 20-hydroxyecdysone (20E), we made a large-scale feeding assay with Japanese quail to find out whether ecdysteroid alone could duplicate the anabolic effects of the seeds. We found that the 96% ecdysteroid increased the mass of the developing quails in a dose-dependent manner, with the rate of increase proportional to the ecdysteroid content in the seeds; there was a 115% increase in living mass with 100 mg kg-1 of pure 20E compared with 109.5% increase with 100-180 mg kg-1 20E equivalents in the seeds. We conclude that the plethora of growth-promoting, vitamin-like effects induced in vertebrates by Leuzea is mediated by ecdysteroids.

[Benpressmannen]

Eksp Klin Farmakol. 1995 Sep-Oct;58(5):46-8.  Related Articles, Links  


[A comparative study of the anabolic action of ecdysten, leveton and Prime Plus, preparations of plant origin]


Gadzhieva RM, Portugalov SN, Paniushkin VV, Kondrat'eva II.

A new class of anabolic substances includes different saponins, originated from Leuzea rhaponticum sp. The effect of these substances on the human body was studied by caliperometric measurements of body folds. All tested substances taken orally for three weeks diminished fat content under conditions of daily aerobic-anaerobic training. Ekdisten and Prime Plus (combination of ekdisten and pure protein) elevated the muscle mass. The same effect of leventon was less pronounced. We showed that all substances studied elevated the magnitude of "total work", estimated per 1 kg of body weight. Ekdisten and Prime Plus again appeared to be most efficient. The prospects of using the saponins in sport medicine are discussed.

[Benpressmannen]

Stephen Garland

Athletes are always on the lookout for safe nutritional supplements that can enhance performance. Now three natural plant extracts known to have positive effects on general health have been tested for their impact on speed and strength performance by a group of Estonian researchers.
The study used extracts of Rhodiola rosea (trade name Arctic Root), Withania somnifera (Ashwaganda) and Rhaponticum cartamoides (Retibol). These substances, collectively known as 'adaptogens', have been shown to increase cell energetics by boosting enzyme concentrations, potassium levels and high-energy phosphate (ATP and phospho-creatine) levels. They also help to maintain optimal quality of muscle mitochondria - the site of the cell's energy production - possess antioxidant properties and help reduce muscle wasting and inflammation.
All of these effects might be expected to improve athletic performance, but very few studies have tested this hypothesis on well-trained athletes. In the Estonian study, three groups of 30 male national-level sprinters, jumpers, ball-players and weight-lifters were asked to take one of the following supplements for 30 days:
Arctic root (940mg/day)
Ashwaganda (360mg/day
Retibol (72mg/day)
Placebo.

The subjects were asked to perform five tests of power before and after the trial period, as follows:
Single squat jump
Counter-movement jump
Rebound jumps for 15 seconds
Maximal work rate when squatting with barbell
30m sprint.

The subjects on active supplements reported that they 'felt much better' when taking them - which might in itself have helped performance or training. However, while subjects taking Retibol showed a small increase in weight (suggesting enhanced muscle mass) and improved their performance in the squatting test, those taking the other two supplements demonstrated no performance benefits at all.
It is possible that the use of Retibol might improve certain aspects of power performance - although the evidence is not strong. It is also possible that untrained subjects might experience more significant benefits than trained ones. But, pending further research, athletes are probably best advised to think twice before investing their hopes - and their cash - in these supplements.
Proceedings of the 5th Annual Congress of the European College of Sport Science, p549-550, 2000

En liten komentar til denne:

Resultatet var faktiskt ganska bra for Retibolgruppen, men økningene var kansje ikke så overdrevent imponerandes dette pga at forsøksperioden bare varte i 30 dager. Forfatteren av texten skrev dessuten i pluralis i sitt sammandrag og det er bara hans tolkning av studiene. En annen hadde kansje tolket det som Kjempepositivt at trænende på elitenivå får slike resultater på bara 30 dager.

[Benpressmannen]

Eksp Klin Farmakol 2000 Jul-Aug;63(4):35-7 Related Articles, Books, LinkOut


[Effect of ecdystene on parameters of the sexual function under experimental and clinical conditions]  

Mirzaev IuR, Syrov VN, Khrushev SA, Iskanderova SD.

Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan.

The effects of ecdysterone and the related drug ecdysten on the sexual activity were studied under experimental and clinical conditions. A 10-day administration of ecdysterone (5 and 10 mg/kg, p.o.) improved behavioral characteristics of the sexual function in rats, the effect being especially pronounced during the fist days of experiment. The administration of ecdysten to men with the infertility diagnosis (disturbed spermatogenesis as a complication of some urologic diseases) increased the copulative function and improved the sperm quality. The administration of ecdysten to patients in the stage of recovery upon myocardial infarction also improved the sexual function

Arch Insect Biochem Physiol 1999;41(3):156-61 Related Articles, Books, LinkOut


20-hydroxyecdysone as a human lymphocyte and neutrophil modulator: In vitro evaluation.

Trenin DS, Volodin VV.

The Centre of Laboratory Diagnostics, Ekaterinburg, The Institute of Biology, Syktyvkar, Russia. aleks@uwc.ru

20-hydroxyecdysone (1 microM) was found to activate in vitro T-cell CD2 presentation, which is suppressed both in secondary immunodeficient persons and pharmacologically by increasing intracellular cAMP levels. The compound was found to act like a synthetic psycho-immunomodulator 1-oxy-4-oxoadamantane (1 microM) and to exceed the effects of the thymomimetic agent levamisol (1 microM). In addition, 20-hydroxyecdysone (1 microM) was also revealed to modulate the fluoride-stimulated respiratory burst of human neutrophils in the same manner as water soluble antioxidants. Arch. Copyright 1999 Wiley-Liss, Inc.

PMID: 10398339 [PubMed - indexed for MEDLINE

Eksp Klin Farmakol 2001 Jul-Aug;64(4):56-8 Related Articles, Books, LinkOut


[Experimental study of pharmacotherapeutic effect of phytoecdisteroids and nerobol in toxic liver damage]

Syrov VN, Khushbaktova ZA.

Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, ul. Kh. Abdulaeva 77, Tashkent, 700170 Uzbekistan.

Phytoecdysteroids ecdysteron and turkesteron isolated from Ajuga turkestanica (Rgl.) Brig. decrease the manifestations of uremic intoxication in rats with experimental renal pathology induced by a nephrotoxic mixture (containing uranyl acetate and glycerol). Injected in a dose of 5 mg/kg, the drugs restore glomerular filtration level, favor the disappearance of the albuminuria and normalize urinary sediments. The nephroprotector effect of the phytoecdysteroids studied resembles the action of a steroidal anabolic drug nerobol.

Eksp Klin Farmakol 1997 May-Jun;60(3):41-4 Related Articles, Books, LinkOut


[The results of experimental study of phytoecdysteroids as erythropoiesis stimulators in laboratory animals]

Syrov VN, Nasyrova SS, Khushbaktova ZA.

Phytoecdysteroids alpha-ecdysone, 2-desoxyecdysterone, ecdysterone, sileneoside A, and turkesterone isolated from Rhaponticum carthamoides (Willd.) IIjin, Silene brahuica Boiss and Ajuga turkestanica (Rgl.) Repeated administration of brig increased the content of erythrocytes and hemoglobin in the blood of intact rats. The most active of them--ecdysterone, sileneoside A, and, particularly turkesterone, cause also a marked effect on red blood regeneration in hemotoxic phenylhydrazine anemia. In its capacity for simulating erythropoiesis turkesterone resembles the well-known steroidal anabolic drug nerobol.

Ukr Biokhim Zh 1992 Jul-Aug;64(4):61-7 Related Articles, Books, LinkOut


[Effect of phytoecdysteroids and nerobol on parameters of carbohydrate and lipid metabolism and phospholipid spectrum of liver mitochondrial membrane in experimental diabetes mellitus of rats]

Syrov VN, Tashmukhamedova MA, Khushbaktova ZA, Mirtalipov DT, Mamatkhanov AU.

Phytoecdysteroids: ecdysterone and turkesterone, introduced orally to male rats with the body mass 180-120 g in a dose of 5 mg/l kg of mass and nerobol in a dose of 10 mg per 1 kg of the mass for 15 days against a background of the developed alloxan diabetes cause a considerable decrease in the content of free fatty acids of the blood serum, sharply increased after the subcutaneous injection of alloxan to the animals (150 mg per 1 kg of the mass). The content of glycogen, malonic dialdehyde, pyruvic acid and calcium transporting function of the liver mitochondria are also normalized. These changes are closely interrelated (and may be mutually conditioned) with the preparation-induced reduction of phospholipid spectrum of the liver mitochondrial membranes pathologically changed owing to insulin insufficiency. In this case phytoecdysteroids in the first turn normalize the fractions of phospholipids which play the structural role in the mitochondrial membranes, and nerobol normalizes the level of minor and monoacylic phospholipids

Probl Endokrinol (Mosk) 1989 Sep-Oct;35(5):77-81 Related Articles, Books, LinkOut


[The effect of nerobol and ecdysterone on insulin-dependent processes linked normally and in insulin resistance]

Kosovskii MI, Syrov VN, Mirakhmedov MM, Katkova SP, Khushbaktova ZA.

The effect of substances with anabolic activity (metandienone and ecdysterone phytoecdysteroid) on the manifestation of insulin effects was studied on a model of insulin resistance in rats induced by injections of hydrocortisone or by insulin insufficiency caused by alloxan. The sensitivity of the body to i. v. infusion of insulin and the reactivity of isolated fatty tissue to the hormone were increased after administration of these substances to test animals. The above effects of steroids were determined by nonspecific synthesis of total proteins in cells rather than by an increase in insulin secretion.

Farmakol Toksikol 1988 Nov-Dec;51(6):57-60 Related Articles, Books, LinkOut


[The action of methandrostenolone and ecdysterone on the physical endurance of animals and on protein metabolism in the skeletal muscles]

Chermnykh NS, Shimanovskii NL, Shutko GV, Syrov VN.

The results of the comparative study on the myotropic activity of methandrostenolone and ecdysterone and their effects on physical endurance of animals suggested that ecdysterone possessing a wider spectrum of the anabolic action on the contractile proteins of the skeletal muscles exerts a more pronounced influence on physical endurance of animals without their preliminary training.

PMID: 3234543 [PubMed - indexed for MEDLINE]

[Benpressmannen]

 
Simakin, S. Yu., et al., "The Combined Use of Ecdisten and the Product 'Bodrost' druing Training in Cyclical Types of Sport." Scientific Sports Bulletin, No. 2, 1998.

Fadeev, B.G., et al., "Comments on the results of Research of Ratibol in the Practice of Athletic Training and Rehabilitation." Natural Sports Research Institute. (In Press)

Smetanin, B. Ya., et al., "The Influence of Preparations of Plant Origin on Physical Work Capacity." The Russian Ministry of Public Health. 1986 (In Press)

Report: "The Influence of Ecdisten, Prime Plus and Prime 1 on the Hormonal Balance of the Organism."

Online: "Erythrocytes." http://www.mcl.tulane.edu/classware...e/Blood/EP.html

Online: Cornelius, Derek. "Bug Juice!!!" http://www.syntrax.com/articles/bugjuice.htm

Andrich, Vince. "20-Beta-Hydroxyecdysterone." Sports Supplement Review., 4th Issue. 8 3 Smetanin, B. Ya., et al., "The Influence of Rehabilitation Remedies on Special Endurance of Speed Skaters." National Research Institute of Sports. (In Press)

Report: "The Pharmacological Attributes of "Ecdisten".

Semeykin, V. A., et al. "Mechanism of Thymolytic action of Anabolic Steroids" Pharmacology and Toxicology, 1991, Vol. 54, 37-38.

[Nocturne]

Hm, vet jeg har sett Syntrabol på en side før, men nå finner jeg ikke linken, noen som vet hvor jeg kan få kjøpt det?

-Noc-

[jens-mulla]

Har du resultatene fra Viru studien (e)? Var det denne Stephen Garland (hvem er dette?) kommenterte?

Etterlyser også *vestlige* studier gjort på *mennesker* som viser *positive* resultater.

[Benpressmannen]

Jeg leter enda etter viru studien, ligger hjemme en plass.
Vist jeg ikke finner den i dag, mailer jeg og spør om en ny kopi.

Det er vel den studien som er mest truverdig av de studiene som er gjort til nå og som er gjort i vest og i tillegg på mennesker!

Jeg er enig i at ecdysten produktene er de som er mest tvilsomme om de virker eller ei, og derfor annbefaler jeg ikke de til nybegynnere og vidrekommne, men kun de som har trent fem år eller mer sammenhengende og som har øvrig kosthold, hvile optimalt, siden de da kjenner kroppen sin meget godt og vet om de for effekt selv eller ei..

Nybegynnere og lett vidrekommende får meget gode resultater nesten uansett hva de gjør, så fremst de trener da.

Jeg var mye skeptisk til bla syntrabol som jeg testet selv, men jeg syntes jeg fikk bra resultater..
Minuset er at det er veldig dyrt i lengden.

[jens-mulla]

I mine øyne er iallefall en studie gjort av en av Viru brødrene høyst troverdig, men jeg er den første til å inrømme at jeg egentlig ikke har noe grunnlag for å bestemme hvorvidt studier av ecdysten er bra gjennomført eller ikke.

"Nybegynnere og lett vidrekommende får meget gode resultater nesten uansett hva de gjør, så fremst de trener da." - hvis bare flere kunne forstå dette  

[Benpressmannen]

Sikkert noen som er nevnt fra før...

Barrington E.J.W. – 1980: Hormones and evolution: after 15 years. In Barrington E.J.W. (ed): Hormones Adaptation and Evolution. Springer, Berlin, Heidelberg. New York, PP. 3-15

Burdette W.J. - 1962b: Effect of invertebrate hormones on vertebrate tissues. Science 139: 987

Burdette W.J. – 1963: Effect of ecdysone incorporation of 14C-Leucine into hepatic protein in vitro. Proc. Soc. Esp. Biol. Med. 112;216-217

Burdette W.J. – 1961:Alteration of the growth of mammalian cells in vitro by ecdysone extract. Nature 189; 666-668

Catalan R.E. – 1979a: Effect of ecdysterone on cyclic AMP and cyclic GMP in mouse plasma. Biochem, Biophys. Res. Comm. 87:1018-1023

Catalan R. E. – 1979b: Effect of ecdysterone on the cyclic AMP – protein kinase system in mouse liver. Biochem. Biophys. Res. Comm. 89: 44-49

Catalan R.E. – 1980: Heterophylic action of ecdysterone . Naturals-senschaften 67:520

Catalan R.E. – 1982: In vitro effect of ecdysterone on protein kinase activity. Comp. Biochem. Physiol (B) 71: 301

Catalan R.E. – 1984: Ecdysterone induces acelylcholines-terase in mammalian brain. Com. Biochem. Physiol. (C) 78: 193-195

Catalan R.E. – 1985: Alterations in rat lipid metabolism following ecdysterone treatment. Comp. Biochem. Physiol. (B) 81:771-775

Chaudhary K.D. – 1969: Effect of ecdysone on glutamic decarboxylase in rat brain. Experientia 25: 250-251.

Cheranyrh N.S. – 1988: Effects of methandrostenolone and ecdysterone on physical endurance of animals and protein metabolism in the skeletal muscles. Farmakol.Toksikol. 6: 57-62

Csaba G. – 1978: Long-lasting effect of single ecdysone injections in newborn rats. Biol. Neonate 33: 170-173

Detmar M. – 1994: Effects of ecdysterone on the differentiation of normal human keralinocyles in vitro.Eur. J. Dermalol, 4:558-562

Dzukharova M.K. – 1987: Pharmacokinetic experiments with ecdysterone. Chim-Farm. 2b. 21: 1163-1167

Fomovska G.N. – 1991: Immunomadulatory effect of ecdysteroids. Ukr. Biokhim Zh. 64: 56-61

Guo F. – 1989: ecdysteroids in medicine and sericiculture. In Kolman J. (ed): Ecdysone – from Chemistry to Mode of Action. Georg Thieme Verlag. Stuttgart. Pp. 442-446

Kandutsch A.A. 1978: Biological activity of some oxygenated sterols. Science 201: 498-501

Kholodova Yu.D. –1979: Phytoecdysteroids – biologically active polyhydroxysteroids. Ukr. Bioch. Zh. 64: 114-117 (in Ukrainian).

Purser D.B. – 1993: Ecdysones used to improve productivity of ruminants. PCT Int.Appl. WO 94 18, 984(Cl. A61K31/575), 01 Sep. 1994, AU Appl. 93/7 19 Feb. 1993, 19p.

Sakhibov A.D. – 1989: Experimental analysis of the immunotropic action of phyloecdysteroids. DOKL. Akad. Nank Uzbek SSR 1989: 55-57

Selepcova L. – 1990: Feeding of Rhaponticum carthamoides Wild and its influence on utility properties in pigs.

Selepcova L. – 1992: The effect of diets with addition of Leuzea carthamoides on development and hislology of internal organs in the rat.

Selepcova L. – 1993: Influence of Rhaponticum carthamoides Wild on the growth of ruminal bacteria in vitro and on fermentation in an artificial rumen.

Simon P. – 1989: Ecdysteroids in vertebrates: pharmacological aspects. In Koolman J. (ed.): Ecdysone – from Chemistry to Mode of Action. Georg Thieme Verlag, Stuttgart, pp. 254-259

Slama K. – 1993:Ecdysteroids:insect hormones, plant defensive factors, or human medicine? Phytoparasiticar 21: 3-8

Syrov V.N. – 1984: Mechanism of the anabolic action of phytoecdysteroids in mammals. Biol. Nauki (Moscow) 11: 16-20

Syrov V.N. – 1976b: Biological activity of cyastetane in experiments on male rats. Biol. Nauki (Moscow) 19(5): 72-74

Syrov V.N. – 1976c: Anabolic activity of phytoecdysone-ecdysterone isolated from Rhaponticum carthamoides. Formakol. Toksikol (Moscow) 39:690-693

Syrov V.N. – 1975a: Effect of ecdysterone on the content of protein, glycogen, and fat in white rat liver, heart & muscle. Dokl. Akad. Nauk Uzbek SSR 32(8): 37-38

Takahashi H. – 1992: Antidiabetic agents containing ecdysterone or inokosterone.

Takei M. – 1991: Effect of ecdysterone on histamine release from rat peritoneal mast cells. J. Pharm. Sci 80: 309-310

Tashmuxelamedova M.A. – 1985: Effect of phytoecdysteroids and anabolic steroids on respiration and oxidative phosphorylation of rat liver milochondria under atloxan-diabetes. Biol. Nauk. 9:37-39

Tashmuxhamedova M.A. – 1986: Effect of phytoecdysteroids and anabolic steroids on activity and stability of membrane – bound enzymes in liver milochondria under conditions of experimental hepatitis. Vopr. Med. Khim. 32: 81-84

Uchiyama M. – 1974: Phytoecdysones and protein metabolism in Mammalia. In Burdette W.J. (ed.): Invertebrate Endocrinology and Hormonal Heterophylly. Springer-Verlag, Berlin,pp.375-398

Uchiyama M. – 1974: Effect of ecdysterone on carbohydrate and lipid metabolism. In Burdette W.J. (ed.): Invertebrate Endocrinology and Hormonal Heterophylly. Springer-Verlag. Berlin, pp. 401-416

Yoshida T. – 1971: Effect of ecdysterone on hyperglycemia in experimental animals. Biochem. Pharmacol. 20: 3263-3268

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Kotsyuruba A.V. – 1992: Effect of ecdysterone on the metabolism of purine and pyrimidine nucleotides in chicken tissues. Ukr. Biochim.Zh 65(5): 52-60

Kotsyuruba A.V. – 1993a: Study of mechanisms of effect of ecdysterone in chickens with hypovitaminosis early action phase. Ukr. Biochim. Zh. 65(5): 83-90

Koudela K. – 1995: Stimulation of growth and development in Japanese quails after oral administration of ecdysteroid-containing diet. Eur. J. Entomol. 92: 349-354

Kudsinau M. A. – 1980: New plants with phytohormonal action for animal breeding. Vesci Akad. Nank BSSR (Ser. Sel’skagosp. Nauk) 1980: 107-110 (in Byelorussian).

Kurmukov A.G. – 1988: Anti-inflammatory properties of ecdysterone. Med. Zh. Uzb. 1988 (10): 68-70



Steroidal ethers:

A. Ercoli, Chemistry and Industry, July 14, 1962 184-1285

Proc. Soc. Exp Biol. Med 1953, 83, 115

Ott, A.C., Murray, M.F. and Pederson J. Amer. Chem Soc. 1952, 74, 1239

A.D. Cross, Worcester Foundation for Experimental Biology, Potent Orally Active Anabolic Steroids, 1964, 229-235.

[Lasse Christoffersen]

Så effedrin er lovlig til en viss grense?Leste på dopinglisten at grensa var på 10 mikrogram per milliliter i urinen...
Hvor stort inntak kan man ta for å ikke overskride den grensa?Trodde effedrin var helt ulovlig jeg da men, da går det vel an å vurdere dette til våren. eller???

[Baahh]

Hvorfor er ikke dette en sticky?

*honnør