Skrevet av Emne: Circadian Timing of Food Intake Contributes to Weight Gain.  (Lest 10738 ganger)

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Circadian Timing of Food Intake Contributes to Weight Gain.
Arble DM, Bass J, Laposky AD, Vitaterna MH, Turek FW.
Center for Sleep and Circadian Biology, Northwestern University, Evanston, Illinois, USA.


Studies of body weight regulation have focused almost entirely on caloric intake and energy expenditure. However, a number of recent studies in animals linking energy regulation and the circadian clock at the molecular, physiological, and behavioral levels raise the possibility that the timing of food intake itself may play a significant role in weight gain. The present study focused on the role of the circadian phase of food consumption in weight gain. We provide evidence that nocturnal mice fed a high-fat diet only during the 12-h light phase gain significantly more weight than mice fed only during the 12-h dark phase. A better understanding of the role of the circadian system for weight gain could have important implications for developing new therapeutic strategies for combating the obesity epidemic facing the human population today.

http://www.ncbi.nlm.nih.gov/pubmed/19730426

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Ja, å snu døgnet og spise mye nattetid (som f.eks. ved skift- og nattarbeid) har jo vært kjent siden lenge at det ikke er særlig bra. Særlig ille for mus som jo har mye raskere metabolisme enn det vi har.


Siterer en kommentar av Lyle Mcdonald på den studien:

"... And a variety of things affect the energy out end of the equation. And the hormonal shifts that happen with things like sleep deprivation is one of them.

As well, partitioning (where calories get stored) throws things off. For example, in many animals, calorie partitioning shifts massively in winter (due to changes in photoperiod measured by melatonin), despite identical caloric intakes they start storing fat. Because the body shifts where incoming calories are 'sent' for storage.

And it's worth noting that rats/mice respond to this type of thing 3-7X faster and more than humans. Which is part of why they are studied, shit happens faster and to a more measurable extent.

And another big part of why it's usually not relevant (e.g. mice have metabolism slow down if they miss a meal, humans do not; but mice lifespan is short so one meal is equal to like a week in humans) or the significance is, well, insignificant."


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