Det finnes allerede en del, og det kommer til å bli mer.
Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans.
Fontana L, Meyer TE, Klein S, Holloszy JO.
Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Little is known regarding the long-term effects of caloric restriction (CR) on the risk for atherosclerosis. We evaluated the effect of CR on risk factors for atherosclerosis in individuals who are restricting food intake to slow aging. We studied 18 individuals who had been on CR for an average of 6 years and 18 age-matched healthy individuals on typical American diets. We measured serum lipids and lipoproteins, fasting plasma glucose and insulin, blood pressure (BP), high-sensitivity C-reactive protein (CRP), platelet-derived growth factor AB (PDGF-AB), body composition, and carotid artery intima-media thickness (IMT). The CR group were leaner than the comparison group (body mass index, 19.6 +/- 1.9 vs. 25.9 +/- 3.2 kg/m(2); percent body fat, 8.7 +/- 7% vs. 24 +/- 8%). Serum total cholesterol (Tchol), low-density lipoprotein cholesterol, ratio of Tchol to high-density lipoprotein cholesterol (HDL-C), triglycerides, fasting glucose, fasting insulin, CRP, PDFG-AB, and systolic and diastolic BP were all markedly lower, whereas HDL-C was higher, in the CR than in the American diet group. Medical records indicated that the CR group had serum lipid-lipoprotein and BP levels in the usual range for individuals on typical American diets, and similar to those of the comparison group, before they began CR. Carotid artery IMT was approximately 40% less in the CR group than in the comparison group. Based on a range of risk factors, it appears that long-term CR has a powerful protective effect against atherosclerosis. This interpretation is supported by the finding of a low carotid artery IMT.
PMID: 15096581 [PubMed - indexed for MEDLINE] [/i]
Jeg er overbevist om at det er noe å hente her. Utfordringen for oss blir å kombinere det med å være muskuløse, ingen vil jo leve 150 år som en pingle på 50 kilo. Jeg tror at en del av effektene kan etterligned ved å holde en lav fettprosent året rundt, med rikelig kardio. Det bør også være et mål å ha gode verdier på de ulike biomarkører, ikke bare i normalt sjikt. Å spise relativt få karbohydrater kan ha en god effekt, jamfør posten min om glykolisering. I tillegg må jo kostholdet være komponert av de riktige matvarene.