Skrevet av Emne: Tilskuddet HMB ser ut til å ha noe for seg.  (Lest 11164 ganger)

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Tilskuddet HMB ser ut til å ha noe for seg.
« : 04. januar 2008, 09:53 »
HMB ser ut til å være sikkert, ha positiv innvirkning på kolesterol og blodtrykk, samt virke antikatabolt ved "muskelspisende" tilstander som kaloriunderskudd. Det finnes også noen studier som viser at det kan øke proteinsyntesen. Anbefalt dosering er 1 g HMB 3 ggr om dagen (totalt 3 g HMB pr dag (eller 38
mg/kg kroppsvekt)).


Litteraturgranskning utført av Wilson, Wilson og Manninen publisert igår (3. januar):

Effects of beta-hydroxy-beta-methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: A review

Nutrition & Metabolism 2008, 5:1doi:10.1186/1743-7075-5-1

The leucine metabolite beta-hydroxy-beta-methylbutyrate (HMB) has been extensively used as an ergogenic aid; particularly among bodybuilders and strength/power athletes, who use it to promote exercise performance and skeletal muscle hypertrophy. While numerous studies have supported the efficacy of HMB in exercise and clinical conditions, there have been a number of conflicting results. Therefore, the first purpose of this paper will be to provide an in depth and objective analysis of HMB research. Special care is taken to present critical details of each study in an attempt to both examine the effectiveness of HMB as well as explain possible reasons for conflicting results seen in the literature. Within this analysis, moderator variables such as age, training experience, various states of muscle catabolism, and optimal dosages of HMB are discussed. The validity of dependent measurements, clustering of data, and a conflict of interest bias will also be analyzed. A second purpose of this paper is to provide a comprehensive discussion on possible mechanisms, which HMB may operate through. Currently, the most readily discussed mechanism has been attributed to HMB as a precursor to the rate limiting enzyme to cholesterol synthesis HMG-coenzyme A reductase. However, an increase in research has been directed towards possible proteolytic pathways HMB may operate through. Evidence from cachectic cancer studies suggests that HMB may inhibit the ubiquitin-proteasome proteolytic pathway responsible for the specific degradation of intracellular proteins. HMB may also directly stimulate protein synthesis, through an mTOR dependent mechanism. Finally, special care has been taken to provide future research implications.


http://www.nutritionandmetabolism.com/content/pdf/1743-7075-5-1.pdf


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Sv: Tilskuddet HMB ser ut til å ha noe for seg.
« #2 : 07. januar 2008, 06:31 »
Jepp


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Sv: Tilskuddet HMB ser ut til å ha noe for seg.
« #3 : 29. april 2009, 10:32 »
Beefcake, har du (eller noen andre) testa ut HMB og evt gjort opp noen erfaringer? Kan det ha noe for seg?

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