Litt forskning på aspartam. Fra pubmed.
Comparing the effects of aspartame and sucrose on motivational ratings, taste preferences, and energy intakes in humans.
Am J Clin Nutr. 1994 Feb;59(2):338-45. Drewnowski A, Massien C, Louis-Sylvestre J, Fricker J, Chapelot D, Apfelbaum M.
Program in Human Nutrition, University of Michigan School of Public Health, Ann Arbor 48109-2029.
This study compared the effects of four breakfast preloads on motivational ratings, taste preferences, and energy intakes of 24 normal-weight nondieting young men and women. The preloads, composed of creamy white cheese (fromage blanc), were either plain or sweetened with aspartame or sucrose. Their energy value was either 1255 or 2929 kJ (300 or 700 kcal). Taste preferences were measured before and 150 min after breakfast. Motivational ratings were obtained at 30-min intervals. The subjects ate lunch, snack, and dinner meals in the laboratory. The consumption of low-energy as opposed to high-energy breakfasts, regardless of sweetness, led to elevated motivational ratings and increased energy intakes at lunch. However, intakes at subsequent meals were the same for all preloads, and no overall compensation in energy was observed. Aspartame did not promote hunger or lead to increased energy intakes in normal-weight subjects.
The effects of aspartame versus sucrose on motivational ratings, taste preferences, and energy intakes in obese and lean women.
Int J Obes Relat Metab Disord. 1994 Aug;18(8 ):570-8. Drewnowski A, Massien C, Louis-Sylvestre J, Fricker J, Chapelot D, Apfelbaum M.
Program in Human Nutrition, School of Public Health, University of Michigan, Ann Arbor 48109.
The study provided no evidence that aspartame promotes hunger or results in increased energy intakes in obese or in lean women
Aspartame--the sweet-tasting dipeptide--does not affect the pancreatic insulin-secreting function
Sadovnikova NV, Fedotov VP, Aleshina LV, Shvachkin IuP, Girin SK.
The action of a synthetic dipeptide aspartam (150 to 180 times as sweet as glucose) on pancreatic insulin-secretory function of rats was studied in vivo and in vitro. The drug was given orally while drinking (300 mg/kg body weight) or was added to the incubation medium of cultivated pancreatic cells (20 mM). It was shown that insulin content in the rat blood serum remained unchanged 10 and 35 minutes after aspartam administration. The drug did not exert any stimulating effect upon insulin secretion following the addition to the pancreatic cell culture medium. It is concluded that aspartam exhibits no direct or mediated action on pancreatic insulin-secretory function.